The Best Medicine For Anxiety Disorders SSRIs and SNRIs such as citalopram, escitalopram and fluoxetine (Prozac) Venlafaxine, citalopram and duloxetine are the first-line treatments for anxiety disorders. Exercise and psychotherapy are important for people suffering from anxiety. Some doctors prescribe antihistamines like hydroxyzine (Atarax or Vistaril). They work by blocking